Marine Microbial Chemical Biology
C2B2 Core Research Area
Marine Microbial Chemical Biology
C2B2 Core Research Area
|
Marine microbial chemical biology is a core area of research at the Center for Chemical Biology and Biotechnology (C2B2). We focus on investigating the distinct metabolic pathways of marine microorganisms, particularly Streptomyces species isolated from coastal sediments in the Philippines also referred as "bacterya sa buhangin". Our biobank contains over 3,000 strains of these sediment-derived Streptomyces, which are known to produce novel natural compounds with significant medicinal potential, including antibiotics, antivirals, and anticancer agents.
These metabolites often exhibit unique modes of action and enhanced potency. We hypothesize that the specific ecological niches of these marine microorganisms influence their metabolite profiles, enabling us to target and isolate bioactive molecules with precision. These natural compounds act by disrupting bacterial cell membranes, inhibiting protein and DNA synthesis, and targeting specific cellular pathways in cancer cells. Our long-term goal is to uncover the molecular and genetic mechanisms that drive the production of these bioactive compounds. By leveraging metabolomics and genomics, we aim to gain deeper insights into the complex biochemical processes within these Streptomyces species from Philippine marine sediments. This knowledge will fuel the discovery of new natural products and biotechnological applications, paving the way for innovative treatments and therapies. |
|
Marine microbial chemical biology is a core area of research at the Center for Chemical Biology and Biotechnology (C2B2). We focus on investigating the distinct metabolic pathways of marine microorganisms, particularly Streptomyces species isolated from coastal sediments in the Philippines also referred as "bacterya sa buhangin". Our biobank contains over 3,000 strains of these sediment-derived Streptomyces, which are known to produce novel natural compounds with significant medicinal potential, including antibiotics, antivirals, and anticancer agents.
These metabolites often exhibit unique modes of action and enhanced potency. We hypothesize that the specific ecological niches of these marine microorganisms influence their metabolite profiles, enabling us to target and isolate bioactive molecules with precision. These natural compounds act by disrupting bacterial cell membranes, inhibiting protein and DNA synthesis, and targeting specific cellular pathways in cancer cells.
Our long-term goal is to uncover the molecular and genetic mechanisms that drive the production of these bioactive compounds. By leveraging metabolomics and genomics, we aim to gain deeper insights into the complex biochemical processes within these Streptomyces species from Philippine marine sediments. This knowledge will fuel the discovery of new natural products and biotechnological applications, paving the way for innovative treatments and therapies.
These metabolites often exhibit unique modes of action and enhanced potency. We hypothesize that the specific ecological niches of these marine microorganisms influence their metabolite profiles, enabling us to target and isolate bioactive molecules with precision. These natural compounds act by disrupting bacterial cell membranes, inhibiting protein and DNA synthesis, and targeting specific cellular pathways in cancer cells.
Our long-term goal is to uncover the molecular and genetic mechanisms that drive the production of these bioactive compounds. By leveraging metabolomics and genomics, we aim to gain deeper insights into the complex biochemical processes within these Streptomyces species from Philippine marine sediments. This knowledge will fuel the discovery of new natural products and biotechnological applications, paving the way for innovative treatments and therapies.
|
|
|
|